Neurological Monitoring Device
The project is carried out in close collaboration between the University Hospital Zurich (USZ) and the Product Development Group Zurich (pd|z). The aim is to develop a new monitoring device that allows to assess early diagnostic indicators after aneurysmal subarachnoid hemorrhage (aSAH).
Delayed ischemic neurological deficits (DIND) worsen outcome in patients with aSAH. Free hemoglobin, which can be measured as oxygenated hemoglobin (oxyHb) contributes critically to the development of DIND. Continuous monitoring of free oxyHb would allow to identify the individual time-profile of erythrolysis in the subarachnoid space in every single patient and therefore to estimate the risk for DIND at every time point of disease.
A continuous monitoring device as a point of care system can lead to a better understanding of the development of DIND. Additionally, these measurements could guide new therapeutic interventions to reduce oxyHb toxicity in aSAH patients.